Belzutifan

产品说明书

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Chemical Structure| 1672668-24-4 同义名 : PT2977; MK-6482
CAS号 : 1672668-24-4
货号 : A1216748
分子式 : C17H12F3NO4S
纯度 : 99%+
分子量 : 383.34
MDL号 : MFCD32197212
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Belzutifan (PT2977), an orally bioavailable and selective inhibitor of HIF-2α, has an IC50 value of 9 nM. As a second-generation HIF-2α inhibitor, it offers enhanced potency and an optimized pharmacokinetic profile. Belzutifan holds promise as a treatment option for clear cell renal cell carcinoma (ccRCC)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.09mL

5.22mL

2.61mL
参考文献

[1]Xu R, et al. 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62(15):6876-6893.