SBI-797812
产品说明书
 |
同义名 : | - |
| CAS号 : | 2237268-08-3 | |
| 货号 : | A1216688 | |
| 分子式 : | C19H22N4O4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 402.47 | |
| MDL号 : | MFCD32197237 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SBI-797812 functions as an orally active activator of nicotinamide phosphoribosyltransferase (NAMPT). It induces a shift in NAMPT activity towards NMN formation, enhances NAMPT's affinity for ATP, stabilizes phosphorylated NAMPT, facilitates the consumption of pyrophosphate by-product, and attenuates feedback inhibition by NAD+. SBI-797812 leads to elevated intracellular nicotinamide mononucleotide (NMN) levels and increased liver NAD+ concentrations in mice[1][2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.48mL 0.50mL 0.25mL |
12.42mL 2.48mL 1.24mL |
24.85mL 4.97mL 2.48mL |
| 参考文献 |
|---|