Raphin1 acetate

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Chemical Structure| 2242616-04-0 同义名 : -
CAS号 : 2242616-04-0
货号 : A1216685
分子式 : C10H12Cl2N4O2
纯度 : 99%+
分子量 : 291.13
MDL号 : MFCD32201062
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Raphin1 acetate, an orally bioavailable, selective PPP1R15B (R15B) regulatory phosphatase inhibitor, binds tightly to the R15B-PP1c holophosphatase (KD=33 nM). It demonstrates approximately 30-fold greater selectivity for R15B-PP1c over R15A-PP1c. Capable of crossing the blood-brain barrier, Raphin1 acetate mitigates both organismal and molecular impairments in a mouse model of protein misfolding disease[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.17mL

3.43mL

1.72mL

34.35mL

6.87mL

3.43mL
参考文献

[1]Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.