Manogepix

产品说明书

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Chemical Structure| 936339-60-5 同义名 : APX001A; E1210; MGX
CAS号 : 936339-60-5
货号 : A1215101
分子式 : C21H18N4O2
纯度 : 98%
分子量 : 358.39
MDL号 : MFCD25977061
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Manogepix represents a novel class of antifungal agents with a unique mechanism of action by inhibiting fungal glycosylphosphatidylinositol (GPI) biosynthesis[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.90mL

5.58mL

2.79mL
参考文献

[1]Watanabe NA, et al. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother. 2012 Feb;56(2):960-71.

[2]Hata K, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother. 2011 Oct;55(10):4543-51.