Afoxolaner

产品说明书

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Chemical Structure| 1093861-60-9 同义名 : NexGard
CAS号 : 1093861-60-9
货号 : A1213607
分子式 : C26H17ClF9N3O3
纯度 : 99%+
分子量 : 625.87
MDL号 : MFCD30533411
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Afoxolaner, an oral isoxazoline targeting Ixodes scapularis in dogs, operates by hindering the uptake of chloride ions regulated by the γ-aminobutyric acid (GABA) and glutamate receptors, causing overexcitement and the eventual demise of the pest[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

7.99mL

1.60mL

0.80mL

15.98mL

3.20mL

1.60mL
参考文献

[1]Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol. 2014 Apr 2;201(3-4):223-5.

[2]Beugnet F, et al. Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs.Parasite. 2014;21:42.