YK-3-237

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Chemical Structure| 1215281-19-8 同义名 : -
CAS号 : 1215281-19-8
货号 : A1209872
分子式 : C19H21BO7
纯度 : 97%
分子量 : 372.18
MDL号 : MFCD28167612
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 YK-3-237 is a SIRT1 activator, specifically targets mutant p53 and curtails the growth of triple-negative breast cancer (TNBC) cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.87mL

5.37mL

2.69mL
参考文献

[1]Yong Weon Yi, et al. Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget. 2013 Jul;4(7):984-94.

[2]Murugavel Ponnusamy, et al. Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis. J Pharmacol Exp Ther. 2015 Aug;354(2):142-51.