SB-657510
产品说明书
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同义名 : | - |
| CAS号 : | 474960-44-6 | |
| 货号 : | A1209761 | |
| 分子式 : | C19H22BrClN2O5S | |
| 纯度 : | 99% | |
| 分子量 : | 505.81 | |
| MDL号 : | MFCD16618389 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SB-657510 is a selective urotensin II receptor antagonist. The Ki values for human, monkey, cat, rat and mouse receptors are 61, 17, 30, 65 and 56 nM, respectively. SB-657510 inhibits UII-induced up-regulation of inflammatory mediators (e.g., adhesion molecules, cytokines, and tissue factors in human vascular endothelial cells), thereby exerting anti-inflammatory effects]1][2].SB-657510 significantly blocked the UII-induced increase in adhesion between U937 cells and EA.hy926 cells. At a concentration of 1 μM for 0.5-8 hours, SB-657510 blocked UII-induced tissue factor expression in endothelial cells[1].SB-657510 inhibited [Ca2+]i migration induced by 10 nM hU-II in the concentration range of 1-10000 nM with an IC50 value of 180 nM[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.98mL 0.40mL 0.20mL |
9.89mL 1.98mL 0.99mL |
19.77mL 3.95mL 1.98mL |
