HQNO
产品说明书
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同义名 : | KF8940; 2-heptyl-4-hydroxyquinoline-N-oxide; Pyo II; N-oxo-2-heptyl-4-Hydroxyquinoline |
| CAS号 : | 341-88-8 | |
| 货号 : | A1209614 | |
| 分子式 : | C16H21NO2 | |
| 纯度 : | 97% | |
| 分子量 : | 259.34 | |
| MDL号 : | MFCD00057295 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Type II NADH: quinone oxidoreductase (NDH-2) is a membrane-bound bi-substrate enzyme that catalyses the cytoplasmic oxidation of NADH and reduction of quinone in the membrane. HQNO is a potent mitochondrial NDH-2 inhibitor in many species. Wide type NDH-2 had an IC50 value of 10.5 ± 1.3 μM HQNO in the presence of 400 μM menadione (MD). In the presence of 50 μM MD, the IC50 value for HQNO decreased slightly to 7.3 ± 1.2 μM and near complete inhibition was observed with > 50 μM HQNO[1]. | ||
| 作用机制 | HQNO is nested into the slot-shaped tunnel of the Q-site, in which the quinone-head group is clamped by Q317 and I379 residues, and hydrogen-bonds to FAD[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.86mL 0.77mL 0.39mL |
19.28mL 3.86mL 1.93mL |
38.56mL 7.71mL 3.86mL |
| 参考文献 |
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