JGB1741
产品说明书
 |
同义名 : | ILS-JGB-1741 |
| CAS号 : | 1256375-38-8 | |
| 货号 : | A1209424 | |
| 分子式 : | C27H24N2O2S | |
| 纯度 : | 99% | |
| 分子量 : | 440.56 | |
| MDL号 : | MFCD02303516 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | JGB1741, also known as ILS-JGB-1741, is a potent, specific inhibitor of SIRT1 activity with an IC50 of 15 μM. JGB1741 is a weak inhibitor of both SIRT2 and SIRT3, with IC50s greater than 100 μM. JGB1741 enhances the level of acetylated p53, leading to p53-mediated apoptosis, and regulates Bax/Bcl2 ratio. JGB1741 increased the level of acetylated p53, led to p53-mediated apoptosis, and regulated Bax/Bcl2 ratio, cytochrome c release and PARP fragmentation. JGB1741 inhibited the proliferation of MDA-MB 231 cells at a concentration of less than 10 μM for 24 h. JGB1741 caused cell cycle arrest in G1 phase, increased the proportion of cells entering sub-G0/G1 phase, and induced apoptosis of MDA-MB 231 cells. At a concentration range of 0.01-1 μM for 24 hours of action, JGB1741 resulted in increased levels of global acetylation of H3K9, p53 expression and acetylated p53K382[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.27mL 0.45mL 0.23mL |
11.35mL 2.27mL 1.13mL |
22.70mL 4.54mL 2.27mL |
