MRT-10
产品说明书
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同义名 : | - |
| CAS号 : | 330829-30-6 | |
| 货号 : | A1209369 | |
| 分子式 : | C24H23N3O5S | |
| 纯度 : | 97% | |
| 分子量 : | 465.52 | |
| MDL号 : | MFCD02734587 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | MRT-10 is a seven-transmembrane receptor smoothened (smo) antagonist with an IC50 value of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the Bodipycyclopamine binding site. MRT-10 can be used in cancer research[1][2].In HEK293 cells, MRT-10 inhibited Smo-induced IP accumulation in a dose-dependent manner with an IC50 value of 2.5 μM. MRT-10 blocked the binding of Bodipy-cyclopamine (5 nM; 2 h) to the expressed mice at a concentration of 10-9-10-5M for 2 h in a dose-dependent manner, binding to cells expressing mouse Smo with an IC50 value of 0.5 μM. Treatment for 40h, MRT-10 inhibited ShhN signalling in Shh-light2 cells in a dose-dependent manner with an IC50 value of 0.64 μM. Treatment for 6 days, MRT-10 inhibited SAG-induced (0.1 μM) alkaline phosphatase (AP) activity in C3H10T1/2 cells with an IC50 value of 0.90 μM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.21mL |
10.74mL 2.15mL 1.07mL |
21.48mL 4.30mL 2.15mL |
