NDT 9513727
产品说明书
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同义名 : | - |
| CAS号 : | 439571-48-9 | |
| 货号 : | A1209368 | |
| 分子式 : | C36H35N3O4 | |
| 纯度 : | 99% | |
| 分子量 : | 573.68 | |
| MDL号 : | MFCD22683794 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | NDT 9513727 is a potent, selective, orally active and competitive human C5aR (C5a receptor) inverse agonist with an IC50 of 11.6 nM. NDT 9513727 can be used for research on human inflammatory diseases. NDT 9513727 inhibits C5a-stimulated responses in various cells, including guanosine 5'-3-O-(thio)triphosphate binding, Ca2+ migration, oxidative quenching, degranulation, cell surface CD11b expression, and chemotaxis, with IC50 values ranging in 1.1 nM- 9.2 nM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.74mL 0.35mL 0.17mL |
8.72mL 1.74mL 0.87mL |
17.43mL 3.49mL 1.74mL |
