SM-7368
产品说明书
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同义名 : | - |
| CAS号 : | 380623-76-7 | |
| 货号 : | A1209325 | |
| 分子式 : | C10H5ClN4O5S | |
| 纯度 : | 97% | |
| 分子量 : | 328.69 | |
| MDL号 : | MFCD00834007 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SM-7368 is a potent NF-kB inhibitor targeting downstream of MAPK p38 activation[1].SM-7368 inhibits TNF-α-induced up-regulation of MMP-9. SM-7368 can be used in chemotherapy studies targeting TNF-α-mediated tumour invasion and metastasis[2].At a concentration of 5 μM, SM-7368 targets downstream of MAPK p38 activation in human colonic crypts (e.g. HT-29 and Caco-2 epithelial cell lines) cells[1].SM-7368 inhibited TNF-α-induced MMP-9 up-regulation in a concentration-dependent manner and showed maximal activity at 10 μM. SM-7368 inhibited a range of TNF-α-induced responses, including MMP-9 mRNA transcript accumulation and protein epitopes, NF-κB activation (but not AP-1 activity), and invasion of the HT1080 cell line[2 ]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.04mL 0.61mL 0.30mL |
15.21mL 3.04mL 1.52mL |
30.42mL 6.08mL 3.04mL |
