SB 218795
产品说明书
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同义名 : | - |
| CAS号 : | 174635-53-1 | |
| 货号 : | A1209207 | |
| 分子式 : | C25H20N2O3 | |
| 纯度 : | 97% | |
| 分子量 : | 396.44 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SB 218795 is a potent and selective non-peptide NK3 receptor antagonist with a Ki value of 13 nM for hNK3. SB 218795 is 90 and 7000 times more selective for hNK3 than hNK2 and hNK1, respectively. SB 218795 inhibits NK3 receptor-mediated pupil constriction in rabbits[1][2].In the concentration range of 3-30 nM, SB 218795 antagonises the contractile response induced by the NK3 receptor agonist Senktide in a surmountable concentration-dependent manner[2].At concentrations of 0.3-3 μM, SB 218795 does not affect the contractile response of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.52mL 0.50mL 0.25mL |
12.61mL 2.52mL 1.26mL |
25.22mL 5.04mL 2.52mL |
