JNJ 303

产品说明书

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Chemical Structure| 878489-28-2 同义名 : -
CAS号 : 878489-28-2
货号 : A1209078
分子式 : C21H29ClN2O4S
纯度 : 99%+
分子量 : 440.98
MDL号 : MFCD18086905
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 JNJ-303 is a specific inhibitor of the delayed rectifier Kv channel, notably blocks IKs with an IC50 value of 64 nM, underlining its high specificity and potential utility in researching conditions like diabetes, obesity, and disorders of the central nervous system[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.34mL

2.27mL

1.13mL

22.68mL

4.54mL

2.27mL
参考文献

[1]Julie Albrecht, et al. The effect of the KV7/KCNE 1 inhibitor JNJ 303 on heart slices and the L-type calcium channel of cardiac cells.

[2]Zhaohuan Huang, et al. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv. 2022 Jun 10;8(23):eabn5345.