MIRA-1
产品说明书
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同义名 : | NSC 19630 |
| CAS号 : | 72835-26-8 | |
| 货号 : | A1208571 | |
| 分子式 : | C8H9NO4 | |
| 纯度 : | 97% | |
| 分子量 : | 183.16 | |
| MDL号 : | MFCD12828765 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | MIRA-1 is a maleimide analogue that induces apoptosis in mutant p53 cells by restoring p53-dependent transcriptional activation. MIRA-1 inhibits the growth of Saos-2-His273 cells expressing mutant p53, and possesses anticancer activity. At a concentration of 5 μM for 14 days, MIRA-1 significantly reduced the number of colonies formed by His273-expressing Saos-2 cells, but was much less effective in inhibiting p53-deficient Saos-2 cells. MIRA-1 induced EGFP expression, MDM2 and Bax in SKOV-His175 cells at concentrations of 5 and 10 μM for 24 hours[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.46mL 1.09mL 0.55mL |
27.30mL 5.46mL 2.73mL |
54.60mL 10.92mL 5.46mL |
