Liproxstatin-1

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Chemical Structure| 950455-15-9 同义名 : -
CAS号 : 950455-15-9
货号 : A120662
分子式 : C19H21ClN4
纯度 : 99%+
分子量 : 340.85
MDL号 : MFCD14948691
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 10 mg/mL clear

PO 0.5% CMC-Na 40 mg/mL suspension

生物活性
靶点

  • Ferroptosis

    ferroptosis, IC50:22 nM
描述 Liproxstatin-1 acts as a powerful inhibitor of ferroptosis, blocking ferroptotic cell death with an IC50 value of 22 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.67mL

2.93mL

1.47mL

29.34mL

5.87mL

2.93mL
参考文献

[1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91.

[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243