同义名 :	-
	CAS号 :	875258-85-8
	货号 :	A1206036
	分子式 :	C24H28FN3O2
	纯度 :	97%
	分子量 :	409.5
	MDL号 :	MFCD27980545
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	YIL781 is a potent orally active antagonist of the ghrelin receptor (GHSR), enhancing glucose homeostasis in rats. It inhibits ghrelin-induced calcium response with pIC50 values of 7.90 and 8.27, respectively [1][2][3][4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.44mL 0.49mL 0.24mL	12.21mL 2.44mL 1.22mL	24.42mL 4.88mL 2.44mL

参考文献

[1]William P Esler, et al. Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss Endocrinology. 2007 Nov;148(11):5175-85. [2]Timothy H. Moran, et al. Gut Peptides: Targets for Antiobesity Drug Development? Endocrinology. 2009 Jun; 150(6): 2526–2530. [3]Elisabetta Perdonà, et al. Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors. Eur J Pharmacol. 2011 Jan 10;650(1):178-83. [4]Yun-Beom Sim, et al. Ghrelin administered spinally increases the blood glucose level in mice. Peptides. 2014 Apr;54:162-5.