CCT007093
产品说明书
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同义名 : | - |
| CAS号 : | 176957-55-4 | |
| 货号 : | A119848 | |
| 分子式 : | C15H12OS2 | |
| 纯度 : | 99% | |
| 分子量 : | 272.39 | |
| MDL号 : | MFCD00121546 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
5% DMSO+corn oil 1 mg/mL |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CCT007093 is PPM1D phosphatase inhibitor with IC50 value of 8.4μM measured by inhibition of phosphorylation of full-length recombinant P38 in the presence of rPPM1D and MgCl2 in an in vitro assay. It showed no inhibitory effect on the phosphatase activity of PPM1A at concentrations as high as 100μM. CCT007093 selectively caused MCF-7cell death, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells, dependent on P38 kinase activity and induced P38 phosphorylation at 25μM post 8h. CCT007093 selectively and potently inhibited colony formation of human tumour cell lines that overexpress PPM1D, including HeLa, MCF-7, KPL-1 and MCF-3B[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.67mL 0.73mL 0.37mL |
18.36mL 3.67mL 1.84mL |
36.71mL 7.34mL 3.67mL |
| 参考文献 |
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