GNF4877
产品说明书
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同义名 : | - |
| CAS号 : | 2041073-22-5 | |
| 货号 : | A1194998 | |
| 分子式 : | C25H27FN6O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 494.52 | |
| MDL号 : | MFCD00078579 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | GNF4877 is a highly potent inhibitor of DYRK1A and GSK3β, with IC50 values of 6 nM and 16 nM, respectively. This inhibition results in the prevention of nuclear factor of activated T-cells (NFATc) nuclear export and enhanced β-cell proliferation (with an EC50 of 0.66 μM for mouse β (R7T1) cells) [1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.11mL 2.02mL 1.01mL |
20.22mL 4.04mL 2.02mL |
| 参考文献 |
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