SR59230A
产品说明书
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同义名 : | - |
| CAS号 : | 174689-39-5 | |
| 货号 : | A1178877 | |
| 分子式 : | C23H29NO6 | |
| 纯度 : | 98% | |
| 分子量 : | 415.48 | |
| MDL号 : | MFCD00940163 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Β3-adrenoceptor is the last identified member of adrenergic receptors, involved in different tumor conditions, such as melanoma[1]. SR59230A is a potent and selective β3-adrenoceptor antagonist with IC50 values of 40, 408, and 648 nM for β3-, β1-, and β2-receptors, respectively[2]. In the NB (neuroblastoma) cell lines, treatment with SR59230A for 24 h was able to reduce cell viability in a dose-dependent manner[1]. In 24-h fasted Wistar rats, both doses (10, 50 nmol) of SR59230A reduced the risk assessment (RA) frequency (number/30 min) (4 ± 2 for saline-treated vs 1 ± 1 for 10 nmol and 0.5 ± 1 for 50 nmol SR59230A-treated rats), an ethological parameter related to anxiety. Further, pretreatment with SR59230A (7.0 ± 0.5 g) abolished the hypophagia induced by BRL37344 (3.6 ± 0.9 g, agonist of β3-adrenoceptor)[2]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.41mL 0.48mL 0.24mL |
12.03mL 2.41mL 1.20mL |
24.07mL 4.81mL 2.41mL |
| 参考文献 |
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