同义名 :	-
	CAS号 :	1203680-76-5
	货号 :	A1177307
	分子式 :	C20H18ClNO2S
	纯度 :	99%+
	分子量 :	371.88
	MDL号 :	MFCD18086887
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

AS1949490 is a highly potent, orally bioavailable inhibitor of SHIP2 phosphatase, displaying IC50 values of 0.34 and 0.62 µM against Mouse and Human SHIP2, respectively. Its selectivity profile shows significantly weaker activity against Human SHIP1, PTEN, synaptojanin, and myotubularin, with no inhibitory effect observed at concentrations above 50 µM for these enzymes. AS1949490 enhances the phosphorylation of Akt, leading to increased glucose consumption and uptake, thereby activating the intracellular insulin signaling pathways. This mechanism underlines its potential utility in diabetes research[1].[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.69mL 0.54mL 0.27mL	13.45mL 2.69mL 1.34mL	26.89mL 5.38mL 2.69mL

参考文献
[1]Suwa A, et, al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol. 2009 Oct;158(3):879-87. [2]Suwa A, et, al. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur J Pharmacol. 2010 Sep 10;642(1-3):177-82.