FGFR1/DDR2 inhibitor 1
产品说明书
 |
同义名 : | - |
| CAS号 : | 2308497-58-5 | |
| 货号 : | A1176996 | |
| 分子式 : | C28H22F3N5O | |
| 纯度 : | 99%+ | |
| 分子量 : | 501.5 | |
| MDL号 : | MFCD32067903 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | FGFR1/DDR2 inhibitor 1 is an orally active FGFR1 and DDR2 inhibitor with IC50 values of 31.1 nM and 3.2 nM, respectively. In the concentration range of 25-200 μM for 2 h, FGFR1/DDR2 inhibitor 1 significantly inhibited FGFR2 phosphorylation in SNU16 cells in a dose-dependent manner. In H2286 cells, FGFR1/DDR2 inhibitor 1 inhibited DDR2 phosphorylation in a dose-dependent manner at a concentration range of 60-250 μM for 2 h. FGFR1/DDR2 inhibitor 1 significantly inhibited the proliferation of FGFR-driven cancer cell lines, and the IC50 values of FGFR1/DDR2 inhibitor 1 were significantly lower than those of FGFR-driven cancer cell lines, and the IC50 values of FGFR2 inhibitor 1 were higher than those of FGFR-driven cancer cell lines, as KG-1, SNU-16, NCI-H716 and UMUC14 with IC50 values of 108.4, 93.4, 31.8 and 306.6 nM, respectively. FGFR1/DDR2 inhibitor 1 showed significant activity against the DDR2-driven cancer cell line NCI-H2286 (IC50=93.0 nM)[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.99mL 0.40mL 0.20mL |
9.97mL 1.99mL 1.00mL |
19.94mL 3.99mL 1.99mL |
