SIRT5 inhibitor 1
产品说明书
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同义名 : | - |
| CAS号 : | 2166487-21-2 | |
| 货号 : | A1176889 | |
| 分子式 : | C31H39FN6O6S2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 674.81 | |
| MDL号 : | MFCD31746885 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sirtuins are protein deacylases that regulate metabolism and stress responses and are implicated in aging-related diseases[1]. SIRT5 has drawn extensive attention due to its specific catalytic activity for low deacetylation activity but significant desuccinylation, demalonylation and deglutarylation activities[2]. SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1[3]. In vivo rat model of ischemia/reperfusion injury, SIRT5 inhibitor 1 (compound 49) reduced the ischemic area, showing a cardioprotective effect against myocardial injury that was higher than that exerted by diazoxide, used as reference cardioprotective drug, and maximum with compound 49[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.48mL 0.30mL 0.15mL |
7.41mL 1.48mL 0.74mL |
14.82mL 2.96mL 1.48mL |
| 参考文献 |
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