NCT-505
产品说明书
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同义名 : | - |
| CAS号 : | 2231079-74-4 | |
| 货号 : | A1176834 | |
| 分子式 : | C27H28FN5O3S | |
| 纯度 : | 95% | |
| 分子量 : | 521.61 | |
| MDL号 : | MFCD31715429 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | NCT-505 is a potent and selective ALDH1A1 inhibitor with an IC50 value of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, and hALDH3A1. NCT-505 is a potent and selective ALDH1A1 inhibitor, with an IC50 value of 7 nM, and weakly inhibits the production of hALDH1A2, hALDH1A3, hALDH2, and hALDH3A1. 5-hydroxyprostaglandin dehydrogenase (HPGD) and type-4 hydroxysteroid dehydrogenase (HSD17β4) were not significantly inhibited by NCT-505 (IC50>57 μM). In addition, NCT-505 showed potent cytotoxicity and reduced the viability of OV-90 cells with EC50 values of 2.10-3.92 μM. NCT-505 was also cytotoxic to SKOV-3-TR cells, with IC50s of 1, 3, 10, 20, and 30 μM in a titration assay[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.92mL 0.38mL 0.19mL |
9.59mL 1.92mL 0.96mL |
19.17mL 3.83mL 1.92mL |
