GSK3145095

产品说明书

Print
Chemical Structure| 1622849-43-7 同义名 : -
CAS号 : 1622849-43-7
货号 : A1176804
分子式 : C20H17F2N5O2
纯度 : 99%+
分子量 : 397.38
MDL号 : MFCD32062741
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 GSK3145095 is a RIP1 kinase inhibitor with an IC50 value of 6.3 nM[1].GSK3145095 effectively blocked the TNF response as evidenced by overall cell survival as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM), and the production of the RIP1-dependent inflammatory cytokine, MIP-1β, both in terms of absolute levels of proteins and multiplicative changes in mRNA expression (IC50 = 0.4 nM). changes (IC50 = 0.4 nM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.58mL

2.52mL

1.26mL

25.16mL

5.03mL

2.52mL