LUT014
产品说明书
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同义名 : | - |
| CAS号 : | 2274819-46-2 | |
| 货号 : | A1176803 | |
| 分子式 : | C27H19F3N8O | |
| 纯度 : | 99%+ | |
| 分子量 : | 528.49 | |
| MDL号 : | MFCD32062738 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BRaf is a protein kinase involved in the regulation of the mitogen activated protein kinase (MAPK) signaling pathway. Mutations in BRaf can induce constitutive signaling through the MAPK pathway which may result in uncontrolled cell proliferation. LUT-014 is a BRaf inhibitor with an IC50 value of 11.7 nM, and developed to reduce dose-limiting acneiform lesions associated epidermal growth factor receptor (EGFR) Inhibitors treatment[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.89mL 0.38mL 0.19mL |
9.46mL 1.89mL 0.95mL |
18.92mL 3.78mL 1.89mL |
| 参考文献 |
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[1]Novel braf inhibitors and use thereof for treatment of cutaneous reactions |