RWJ 50271
产品说明书
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同义名 : | - |
| CAS号 : | 162112-37-0 | |
| 货号 : | A1176671 | |
| 分子式 : | C18H17F3N4O2S | |
| 纯度 : | 99%+ | |
| 分子量 : | 410.41 | |
| MDL号 : | MFCD00938572 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | RWJ 50271 is a selective, orally active inhibitor of LFA-1/ICAM-1 interaction with an IC50 value of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion. RWJ 50271 inhibits the binding of plastic immobilised SICAM to peripheral blood lymphocytes. RWJ 50271 inhibits peripheral blood lymphocyte adhesion to plastic immobilised SICAM-1. RWJ 50271 inhibits human and murine NK activity in an LFA-1/ICAM-1-dependent natural killer cytotoxicity assay (IC50=5.0 μM). RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X, or VLA-4/VCAM-1 mediated cell adhesion at 20 μM. It does not alter the expression level of LFA-1 in HL60 cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.44mL 0.49mL 0.24mL |
12.18mL 2.44mL 1.22mL |
24.37mL 4.87mL 2.44mL |
