PhiKan 083 HCl
产品说明书
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同义名 : | PhiKan 083 hydrochloride |
| CAS号 : | 1050480-30-2 | |
| 货号 : | A1176637 | |
| 分子式 : | C16H19ClN2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 274.79 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PhiKan 083 HCl is a carbazole derivative that binds to surface cavities and stabilises the p53 Y220C mutant with a Kd value of 167 μM[1].PhiKan 083 HCl has a Kd value of 150 μM in Ln229 cells. At a concentration of 125 μM for 48 hours, PhiKan 083 HCl reduces the cell viability of the engineered variants of Ln229 cells. PhiKan 083 (100 μM) in combination with NSC 123127 (1 μM) enhances the pro-apoptotic activity of all variants of Ln229 cells ( p53wt, p53Y220C, p53G245S, p53R282W). After 48 hours of action, it resulted in a 70 ± 5% reduction in viability of Ln229 variant cells[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.64mL 0.73mL 0.36mL |
18.20mL 3.64mL 1.82mL |
36.39mL 7.28mL 3.64mL |
