SCH28080
产品说明书
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同义名 : | - |
| CAS号 : | 76081-98-6 | |
| 货号 : | A1176583 | |
| 分子式 : | C17H15N3O | |
| 纯度 : | 99%+ | |
| 分子量 : | 277.32 | |
| MDL号 : | MFCD00834620 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SCH28080 is a reversible K+-competitive inhibitor of gastric H,K-ATPase with a Ki value of 0.12 μM.SCH28080 is a potent in vivo inhibitor of gastric acid secretion with anti-gastric ulcer activity[1][2][3].SCH28080 inhibits histamine-induced uptake of [14C]aminopyrine in isolated rabbit parietal cells with an IC50 of 0.029 μM[1].SCH28080 resulted in a dose-dependent decrease in cell viability, with IC50 values of 22.9 µM and 15.3 µM after 2 and 24 h of treatment, respectively, and cell viability was already below 10% at 100 µM after 2 h of treatment.SCH28080 inhibited insulin secretion through activation of IK ATP and inhibition of L-type voltage-gated Ca2+ channels, decreased cell viability and dose-dependently induces apoptosis/necrosis and is cytotoxic at higher doses[2] . | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.61mL 0.72mL 0.36mL |
18.03mL 3.61mL 1.80mL |
36.06mL 7.21mL 3.61mL |
