Mito-TEMPO

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Chemical Structure| 1334850-99-5 同义名 : -
CAS号 : 1334850-99-5
货号 : A1173173
分子式 : C29H35ClN2O2P
纯度 : 98%+
分子量 : 510.03
MDL号 : MFCD26406410
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties. This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria[1]. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species[2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.96mL

0.39mL

0.20mL

9.80mL

1.96mL

0.98mL

19.61mL

3.92mL

1.96mL
参考文献

[1]Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radic. Biol. Med. 51(7), 1289-1301 (2011)

[2]Liang, H.L., Arsenault, J., Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14(10), 1176-1189 (2009).

[3]Dikalova, A.E., Bikineyeva, A.T., Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ. Res. 107(1), 106-116 (2010).

[4]Liang, H.L., Sedlic, F., Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radic. Biol. Med. 49(10), 1550-1560 (2010).