BMS-1166

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	同义名 :	-
	CAS号 :	1818314-88-3
	货号 :	A1168529
	分子式 :	C₃₆H₃₃ClN₂O₇
	纯度 :	99%+
	分子量 :	641.11
	MDL号 :	MFCD31746874
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
靶点	PD-1/PD-L1 interaction PD-1/PD-L1 interaction, IC50:1.4 nM PD-1/PD-L1 interaction PD-1/PD-L1 interaction, IC50:1.4 nM PD-1/PD-L1 interaction PD-1/PD-L1 interaction, IC50:1.4 nM
描述	BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces PD-L1 dimerisation and blocks its interaction with PD-1 with an IC50 of 1.4 nM. BMS-1166 antagonises the inhibitory effect of PD-1/PD-L1 immune checkpoints on T-cell activation^[1]^[2].BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in homogenous time-resolved fluorescence binding assay^[1].BMS-1166 antagonises the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose-dependently abrogates the inhibitory effect of sPD-L1 on EC stimulation^[2].

实验方案

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.56mL

0.31mL

0.16mL

7.80mL

1.56mL

0.78mL

15.60mL

3.12mL

1.56mL

✕

靶点

靶点	数值

PD-1/PD-L1 interaction	PD-1/PD-L1 interaction, IC50:1.4 nM
PD-1/PD-L1 interaction	PD-1/PD-L1 interaction, IC50:1.4 nM
PD-1/PD-L1 interaction	PD-1/PD-L1 interaction, IC50:1.4 nM