(R)-Viloxazine HCl
产品说明书
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同义名 : | (R)-Viloxazine hydrochloride |
| CAS号 : | 56287-63-9 | |
| 货号 : | A1167354 | |
| 分子式 : | C13H20ClNO3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 273.76 | |
| MDL号 : | MFCD18379655 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | (R) -Viloxazine Hydrochloride is R(+)-isomers of the atypical antidepressant viloxazin. The S(-)-isomer appeared 5 times as active as the R(+)-isomer under acute administration. In chronic administration, (15 days), the R(+)-isomer appeared ineffective. Comparison of the affinity of the racemate, R(+) and S(-)-isomers for alpha 1-, alpha 2- and beta-adrenoreceptors, as well as for serotonin, C1, benzodiazepine, imipramine and dopamine receptors did not demonstrate any stereospecificity of viloxazin isomers[2]. Viloxazine extended-release (viloxazine ER, SPN-812) is a novel non-stimulant with activity at serotonin receptors and the norepinephrine transporter, which is under investigation as a potential treatment for attention-deficit/hyperactivity disorder. oadministration of viloxazine ER and methylphenidate did not impact the pharmacokinetics of viloxazine or methylphenidate relative to administration of either drug alone. The combination appeared to be safe and well tolerated[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.65mL 0.73mL 0.37mL |
18.26mL 3.65mL 1.83mL |
36.53mL 7.31mL 3.65mL |
| 参考文献 |
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