RO-3
产品说明书
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同义名 : | - |
| CAS号 : | 1026582-88-6 | |
| 货号 : | A1167270 | |
| 分子式 : | C16H22N4O2 | |
| 纯度 : | 98%+ | |
| 分子量 : | 302.37 | |
| MDL号 : | MFCD12828747 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | RO-3 is described as a strong, central nervous system-penetrating, and orally administered antagonist of the P2X3 and P2X2/3 receptors, demonstrating pIC50 values of 5.9 and 7.0 against human P2X3 and P2X2/3 receptors, respectively. This compound is distinguished by its selectivity towards P2X3 and P2X2/3 receptors, showing no significant activity against other P2X receptor types (IC50 >10 μM for P2X1,2,4,5,7)[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.31mL 0.66mL 0.33mL |
16.54mL 3.31mL 1.65mL |
33.07mL 6.61mL 3.31mL |
| 参考文献 |
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