J14

产品说明书

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Chemical Structure| 1043854-13-2 同义名 : -
CAS号 : 1043854-13-2
货号 : A1157030
分子式 : C28H25ClN4O2S
纯度 : 99%+
分子量 : 517.04
MDL号 : MFCD19814303
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

IP 10%DMSO + 35%PEG400 + 10%tween80 + 45%Water 5 mg/mL clear

生物活性
描述 J14 is a reversible inhibitor of sulfiredoxin, exhibiting an IC50 of 8.1 μM. By inhibiting sulfiredoxin, J14 induces oxidative stress (intracellular ROS accumulation), resulting in cytotoxicity and cancer cell death[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.67mL

1.93mL

0.97mL

19.34mL

3.87mL

1.93mL
参考文献

[1]Kim H, et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74.