TLR7/8 agonist 1 2HCl
产品说明书
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同义名 : | TLR7/8 Agonist 1 (hydrochloride); TLR7/8 agonist 1 dihydrochloride; TLR7/8 agonist-5d |
| CAS号 : | 1620278-72-9 | |
| 货号 : | A1151906 | |
| 分子式 : | C22H27Cl2N5 | |
| 纯度 : | 99%+ | |
| 分子量 : | 432.39 | |
| MDL号 : | MFCD31657341 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | TLR7/8 agonist 1 2HCl is a TLR7/TLR8 dual antagonist of imidazoquinolines[1][2].TLR7/8 agonist 1 2HCl has significant immunostimulatory activity. TLR7/8 Agonist 1 2HCl is a flexible precursor that can be covalently linked to fluorophores without significant loss of activity. TLR7/8 Agonist 1 2HCl can be directly linked with commercial fluorescein isothiocyanate and TLR7/8 Agonist 1 2HCl can be covalently coupled directly to commercial fluorescein isothiocyanate and rhodamine B isothiocyanate. TLR7/8 Agonist 1 2HClretains TLR7 antagonistic activity with an EC50 of 20 nM[1].TLR7/8 agonist 1 2HCl has agonistic potency against human TLR7/8 with IC50 values of 50 nM and 55 nM, respectively[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.31mL 0.46mL 0.23mL |
11.56mL 2.31mL 1.16mL |
23.13mL 4.63mL 2.31mL |
