Cephradine

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Chemical Structure| 38821-53-3 同义名 : Cefradine; SQ-11436; Velosef; Cephradin; Anspor; Sefril
CAS号 : 38821-53-3
货号 : A114890
分子式 : C16H19N3O4S
纯度 : 98%
分子量 : 349.4
MDL号 : MFCD00865048
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Cefradine is a major group of widely used β-lactam antibiotics[3]. The specific growth rate of C. reinhardtii slightly increased with cefradine concentrations within the range 0.5 - 10 mg/L[4]. Cefradine can inhibit SUV-induced (ultraviolet) skin inflammation by blocking TOPK (T-LAK cell-originated protein kinase) signaling pathway, and TOPK is an effective target for suppressing inflammation induced by SUV irradiation[5]. After a single bolus injection of two grams of cefradine the concentrations of antibiotic in serum and renal tissues of 21 patients were estimated. The estimated cefradine concentrations in serum and in normal and impaired renal tissue within the time interval of 10 to 90 minutes are above the minimal inhibition concentrations for most cefradine sensitive pathogens[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL
参考文献

[1]Han HK, Rhie JK, et al. CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50.

[2]Hassert GL, DeBaecke PJ, et al. Toxicological, pathological, and teratological studies in animals with cephradine. Antimicrob Agents Chemother. 1973 Jun;3(6):682-5.

[3]Dudkowska J, Frańska M, Frański R. Detection of the iron complexes with hydrolysis products of cephalexin and cefradine upon high-performance liquid chromatography/electrospray ionization mass spectrometry analysis. Rapid Commun Mass Spectrom. 2018;32(7):576–582

[4]Cao J, Jiang R, Wang J, et al. Study on the interaction mechanism between cefradine and Chlamydomonas reinhardtii in water solutions under dark condition. Ecotoxicol Environ Saf. 2018;159:56–62

[5]Fan X, Duan Q, Ke C, et al. Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase. Oncotarget. 2016;7(17):24633–24645

[6]Adam D, Tunn U. Konzentrationen von Cefradin im Nierengewebe [Concentrations of cefradine in renal tissue (author's transl)]. MMW Munch Med Wochenschr. 1979;121(42):1367–1369