Fasudil HCl semihydrate
产品说明书
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同义名 : | HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrate; Fasudil hydrochloride hydrate; Fasudil hydrochloride hemihydrate; Eril-S |
| CAS号 : | 186694-02-0 | |
| 货号 : | A1148848 | |
| 分子式 : | C28H38Cl2N6O5S2 | |
| 纯度 : | 98% | |
| 分子量 : | 673.67 | |
| MDL号 : | MFCD30747910 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fasudil hydrochloride semihydrate is a non-specific RhoA/ROCK inhibitor, which also inhibits protein kinases, with a Ki of 0. 33 μM for ROCK1, and IC50s of 0. 158 μM and 4. 58 μM for ROCK2 and 12. 30 μM for PKA, PKC, and PKG, respectively, Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator[1][2][3]. Fasudil hydrochloride semihydrate at a concentration of 100 μM inhibited cell spreading, stress fibre formation and α-SMA expression in rat haematopoietic stem cells (hepatic stellate cells) and human haematopoietic stem cell-derived TWNT-4 cells, as well as inhibiting cell growth. Fasudil hydrochloride semihydrate in the concentration range of 50-100 μM for 24 hours was shown to inhibit cell growth. Fasudil hydrochloride semihydrate at 50-100 μM for 24 hours inhibited LPA (lysophosphatidic acid)-induced phosphorylation of ERK1/2, JNK, and p38. Fasudil hydrochloride semihydrate at 25-100 μM for 24 hours inhibited the transcription of collagen and TIMP, and stimulated the transcription of MMP-1 in human haematopoietic stem cell-derived TWNT-4 cells[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.48mL 0.30mL 0.15mL |
7.42mL 1.48mL 0.74mL |
14.84mL 2.97mL 1.48mL |
