Pinacidil monohydrate

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Chemical Structure| 85371-64-8 同义名 : 吡那地尔水合物 ;P-1134 monohydrate; Pinacidil (hydrate)
CAS号 : 85371-64-8
货号 : A1143146
分子式 : C13H21N5O
纯度 : 99%+
分子量 : 263.34
MDL号 : MFCD00242745
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Pinacidil monohydrate is known as a potassium channel activator[1]. Pinacidil hydrate is classified as an antihypertensive agent, belonging to the potassium channel openers group[2]. Pinacidil hydrate activates ATP-modulated potassium channels in guinea pig bladder and heart with Ki values of 104 nM and 251 nM, respectively[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.80mL

0.76mL

0.38mL

18.99mL

3.80mL

1.90mL

37.97mL

7.59mL

3.80mL
参考文献

[1]Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86.

[2]Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5.

[3]Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92.