同义名 :	苯硫胍 ;Rintal; Combotel; Febantel (USAN/INN).; Rintal (TN); Paste; Febantelum; Febantelum [INN-Latin]; Negabot Plus; Bay Vh 5757; Oratel
	CAS号 :	58306-30-2
	货号 :	A110936
	分子式 :	C20H22N4O6S
	纯度 :	98+%
	分子量 :	446.48
	MDL号 :	MFCD01738527
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Febantel is widely used anthelmintic drug active against a range of gastrointestinal parasites in animals[3]. The febantel tablet decreased the hookworm egg count by 99.9% and the whipworm egg count by 100%. The controlled test efficacies of febantel tablets against Ancylostoma caninum, Ancylostoma braziliense, and Trichuris vulpis were, 98.2%, 100% and 99.7%, respectively[4]. Febantel was rapidly cleared from the circulation and highly metabolized. The efficacy against Ascaridia was 100% for the faecal egg count reduction (FECR) as well as for the worm reduction in all treated pigeons. After two treatments with febantel against Capillaria in heavily infected pigeons the FECR amounted to 96.7% and worm reduction was 95%. In order to effectively remove both parasites from the host, repeated treatments with febantel at a short interval could be the treatment of choice[5]. Febantel alone, effectively eliminated Giardia trophozoites at 160 and 80 mg/kg mongolian gerbils. Febantel combined with pyrantel embonate effectively eliminated Giardia trophozoites at 160, 80 and 40 mg/kg. However, febantel is more effective in elimination of Giardia infections when combined with pyrantel embonate compared to the agents used alone[6].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.24mL 0.45mL 0.22mL	11.20mL 2.24mL 1.12mL	22.40mL 4.48mL 2.24mL

参考文献

[1]Ben-Zvi Z, Gussarsky E, et al. The bioavailability of febantel in dehydrated camels. J Vet Pharmacol Ther. 1996 Aug;19(4):288-94. [2]Chartier C, Kulo A, et al. Individual fluctuations in efficacy of febantel against Muellerius capillaris in goats. Vet Res. 1995;26(2):116-23. [3]Babić S, Pavlović DM, Biošić M, Ašperger D, Škorić I, Runje M. Fate of febantel in the aquatic environment-the role of abiotic elimination processes. Environ Sci Pollut Res Int. 2018;25(29):28917‐28927 [4]Greiner EC, Brenner DG, Cox DD, Heaton-Jones DL. Comparison of febantel tablets and Vercom paste against gastrointestinal nematodes of dogs. Vet Parasitol. 1992;41(1-2):151‐156 [5]Baert L, Van Poucke S, Vermeersch H, et al. Pharmacokinetics and anthelmintic efficacy of febantel in the racing pigeon (Columba livia). J Vet Pharmacol Ther. 1993;16(2):223‐231 [6]Olson ME, Heine J. Synergistic effect of febantel and pyrantel embonate in elimination of Giardia in a gerbil model. Parasitol Res. 2009;105 Suppl 1:S135‐S140