同义名 :	TIZ; NSC 697856; Desacetyl-nitazoxanide
	CAS号 :	173903-47-4
	货号 :	A108453
	分子式 :	C10H7N3O4S
	纯度 :	98%
	分子量 :	265.25
	MDL号 :	MFCD07484970
	存储条件：	Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Tizoxanide is the main active metabolite of nitazoxanide. Nitazoxanide and tizoxanide have a broad-spectrum anti-infective effect, including parasites, bacteria, and virus. Tizoxanide exerts anti-inflammatory effects, by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated (lipopolysaccharide) macrophage cells[3]. Tizoxanide (TIZ) inhibited virus replication of all CIVs (canine influenza virus) with 90% inhibitory concentrations ranging from 0.60 to 0.76 μM, and it is effective against CIV and may be useful for treatment of canine influenza in dogs[4]. TIZ exhibited potent inhibition of both HBV (hepatitis B virus) and HCV (hepatitis C virus) replication[5]. Tizoxanide showed potent in vitro antiviral activity against all influenza viruses tested. Median EC50 values (±IQR) of 0.48 μM (0.33-0.71), 0.62 μM (0.56-0.75), 0.66 μM (0.62-0.69), and 0.60 μM (0.51-0.67) were obtained for A(H1N1)pdm09, A(H3N2), B(Victoria lineage), and B(Yamagata lineage) influenza viruses respectively[6].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02684240	Tuberculosis	Phase 2	Completed	-	Haiti ... 展开 >> Les Centres GHESKIO Port-au-Prince, Haiti 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.77mL 0.75mL 0.38mL	18.85mL 3.77mL 1.89mL	37.70mL 7.54mL 3.77mL

参考文献

[1]Ashton LV, Callan RL, et al. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010 Aug 12;2010. [2]Korba BE, Montero AB, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63. [3]Shou J, Kong X, Wang X, et al. Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation. Inflammation. 2019;42(4):1336–1349 [4]Ashton LV, Callan RL, Rao S, Landolt GA. in vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010;2010:891010. Published 2010 Aug 12 [5]Korba BE, Montero AB, Farrar K, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008;77(1):56–63 [6]Tilmanis D, van Baalen C, Oh DY, Rossignol JF, Hurt AC. The susceptibility of circulating human influenza viruses to tizoxanide, the active metabolite of nitazoxanide. Antiviral Res. 2017;147:142–148