同义名 :	-
	CAS号 :	1258275-73-8
	货号 :	A107582
	分子式 :	C21H32O6
	纯度 :	98%+
	分子量 :	380.48
	MDL号 :	-
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

TMPA is characterized as a high-affinity antagonist of Nur77, a mechanism that prompts the liberation and translocation of LKB1 into the cytoplasm, thereby activating AMPKα. This action has significant implications for diabetes management, as TMPA effectively reduces blood glucose levels and mitigates insulin resistance in various models of diabetes, including type II db/db, high-fat diet, and streptozotocin-induced diabetic mice. Furthermore, TMPA demonstrates potential therapeutic value in cancer and T-cell apoptosis regulation by diminishing restimulation-induced cell death (RICD) in human T cells[1][2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.63mL 0.53mL 0.26mL	13.14mL 2.63mL 1.31mL	26.28mL 5.26mL 2.63mL

参考文献
[1]Zhan YY, et al. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol. 2012 Nov;8(11):897-904. [2]Recher, et al. Modulation of T-cell apoptosis by small molecule compounds targeting the nuclear orphan receptor Nur 77. (2018).