Geraniol

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Chemical Structure| 106-24-1 同义名 : β-Geraniol; NSC 9279; (E)-Geraniol
CAS号 : 106-24-1
货号 : A107131
分子式 : C10H18O
纯度 : 95%
分子量 : 154.25
MDL号 : MFCD00002917
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Geraniol is a monoterpenic alcohol and has the activity of geraniol against prostate, bowel, liver, kidney and skin cancer. It can induce apoptosis and increase the expression of proapoptotic proteins[3]. The treatment of geraniol inhibited the expression of IL-1β-induced PGE2, NO, COX-2, iNOS, TNF-α and IL-6. Besides, geraniol inhibited the expression of MMP-9 and ADAMTS-5, and reversed the degradation of aggrecan and type II collagen. Geraniol suppressed IL-1β-stimulated PI3K/Akt/NF-κB and MAPK activation[4]. Histopathological examination revealed that simultaneous treatment with geraniol in AlCl3 intoxicated rats ameliorate the liver lesions such as necrosis, inflammatory cell infiltration, vacuolar degeneration, along with hyperemia and the cell density of the Langerhans islands[5]. Geraniol significantly promoted the recovery of neuronal function and attenuated neuropathic pain after SCI(spinal cord injury) [6]. Geraniol (25, 50 and 100 mg/kg) exerted a depressant effect on the central nervous system of rats[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.48mL

1.30mL

0.65mL

32.41mL

6.48mL

3.24mL

64.83mL

12.97mL

6.48mL
参考文献

[1]Hagvall L, Brared Christensson J. Cross-reactivity between citral and geraniol - can it be attributed to oxidized geraniol? Contact Dermatitis. 2014 Nov;71(5):280-8.

[2]Dai M, Peng C, et al. Anti-Trichomonas vaginalis properties of the oil of Amomum tsao-ko and its major component, geraniol. Pharm Biol. 2016;54(3):445-50.

[3]Mączka W, Wińska K, Grabarczyk M. One Hundred Faces of Geraniol. Molecules. 2020 Jul 21;25(14):3303

[4]Wu Y, Wang Z, Fu X, Lin Z, Yu K. Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies. Int Immunopharmacol. 2020 Sep;86:106713

[5]Hosseini SM, Hejazian LB, Amani R, Siahchehreh Badeli N. Geraniol attenuates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride-hepatopancreatic toxicity in male Wistar rats. Environ Sci Pollut Res Int. 2020 Jun;27(16):20076-20089

[6]Lv Y, Zhang L, Li N, Mai N, Zhang Y, Pan S. Geraniol promotes functional recovery and attenuates neuropathic pain in rats with spinal cord injury. Can J Physiol Pharmacol. 2017 Dec;95(12):1389-1395

[7]Medeiros KAAL, Dos Santos JR, Melo TCS, de Souza MF, Santos LG, de Gois AM, Cintra RR, Lins LCRF, Ribeiro AM, Marchioro M. Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra. Biomed J. 2018 Oct;41(5):298-305