ICCB-19 HCl

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Chemical Structure| 1803605-68-6 同义名 : ICCB-19 hydrochloride
CAS号 : 1803605-68-6
货号 : A1066030
分子式 : C12H22ClN3OS
纯度 : 99%+
分子量 : 291.84
MDL号 : MFCD28145281
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. It binds to the N-terminal domain of TRADD (TRADD-N), disrupting its interaction with both TRADD-C and TRAF2. ICCB-19 hydrochloride indirectly inhibits RIPK1 kinase activity, effectively inducing autophagy and the degradation of long-lived proteins[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.13mL

3.43mL

1.71mL

34.27mL

6.85mL

3.43mL
参考文献

[1]Daichao Xu, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587(7832):133-138.