同义名 :	-
	CAS号 :	5631-68-5
	货号 :	A100991
	分子式 :	C9H10O4
	纯度 :	97%
	分子量 :	182.17
	MDL号 :	MFCD00143017
	存储条件：	Pure form Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Syn-2,3-dihydroxy-3 - (3,4-dihydroxyphenyl) propionic acid (m-DGA) is a synthetic derivative of chemical poly [3 - (3,4-dihydroxyphenyl) glyceric acid] (p-DGA). Both p-DGA and m-DGA inhibited the growth and induced death of prostate cancer cells, caused G1 phase arrest of PCa cells by regulating the expression of cell cycle regulators. Moreover, m-DGA (50 and 100 µg/mL) decreased 22Rv1 cell growth by 12–34% and 43–61% after 24 and 48h of treatment[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	5.49mL 1.10mL 0.55mL	27.45mL 5.49mL 2.74mL	54.89mL 10.98mL 5.49mL

参考文献

[1]Chen X, Haniu A, et al. The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition. Z Naturforsch C. 2017 Mar 1;72(3-4):119-121. [2]Dann O, Volz G. A new synthesis of psoralene [(author's transl)] . Arch Pharm (Weinheim). 1975 Feb;308(2):121-30. German. [3]Shrotriya S, Gagan D, Ramasamy K, Raina K, Barbakadze V, Merlani M, Gogilashvili L, Amiranashvili L, Mulkijanyan K, Papadopoulos K, Agarwal C, Agarwal R. Poly[3-(3, 4-dihydroxyphenyl) glyceric acid] from Comfrey exerts anti-cancer efficacy against human prostate cancer via targeting androgen receptor, cell cycle arrest and apoptosis. Carcinogenesis. 2012 Aug;33(8):1572-80. doi: 10.1093/carcin/bgs202. Epub 2012 Jun 12. PMID: 22693258; PMCID: PMC3499058.