3-Methyltoxoflavin
产品说明书
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同义名 : | - |
| CAS号 : | 32502-62-8 | |
| 货号 : | A1005353 | |
| 分子式 : | C8H9N5O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 207.19 | |
| MDL号 : | MFCD00449892 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 3-Methyltoxoflavin is a potent PDI inhibitor with an IC50 value of 170 nM. 3-Methyltoxoflavin is toxic to human glioblastoma cell lines. Bru-seq analysis showed that 3-Methyltoxoflavin induced Nrf2 antioxidant response, ER stress response and autophagy. Specifically, 3-Methyltoxoflavin upregulated the transcription and protein expression of heme oxygenase 1 and SLC7A11, and inhibited PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death is not through apoptosis or necrosis, but through a hybrid process of autophagy and iron metamorphosis[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.83mL 0.97mL 0.48mL |
24.13mL 4.83mL 2.41mL |
48.26mL 9.65mL 4.83mL |
