GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPARγ, respectively.

Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPARγ) with Kd of 40 nM and it also acts as a modulator of TRP channels.

CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPARγ agonist.

BADGE is a PPARγ antagonist.

SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity.

AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. It is potential for Duchene Muscular Dystrophy treatment.

DG172 2HCl is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties.

GW7647 is a potent human PPARα agonist with EC50 value of 6nM.

GW0742 is an agonist of PPARδ with EC50 of 1.1 nM. It can protect right heart from hypertrophy and enhance lipid metabolism in heart. It also works as an antagonist of vitamin D receptor.

GSK0660 is a selective antagonist of PPARβ/δ and exhibits inverse agonist effects when used alone.

Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor δ (PPARδ) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.

Astaxanthin is a carotenoid pigment found primarily in marine organisms including Haematococcus Pluvialis, shrimp and salmon. It is a potent lipid-soluble antioxidant.

Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPARγ, EC50 = 500-600 nM) over PPAR⍺. It also a thiazolidinedione (TZD) anti-diabetic.

Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon.

Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2].

PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity.

(Z)-Falcarindiol, a natural product isolated and purified from carrots, induces cell death in breast cancer cells with enhanced endoplasmic reticulum stress involved in autophagy.