LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM).

IWP-O1 is highly potent Porcn inhibitor with EC50 value of 80 pM.

IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.

ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.

Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A activation (IC50 = 74 pM).

Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.

GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.

IWP 12 is a potent inhibitor of Porcupine (PORCN) with IC50 of 15 nM.