Platycodin D is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90/cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70.