NSC 87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Rbin-1 inhibits ATPase with GI50 of 136±7 nM, it is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis.

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 enzyme with IC50 value of 0.58 nM, without activity against the SHP2 catalytic domain up to a concentration of 10 µM.

BR-1 is a cell-permeable PRL-3 inhibitor with IC50 value of 900nM. It dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration.

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

FRJ is a specific inhibitor of protein tyrosine phosphatase 1B (PTP1B).

PHPS1 is a potent and selective SHP2 inhibitor with Ki value of 0.73μM.

BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09 - 1.7 μM, displaying irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. BVT 948 enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo.

SMAP is a potent and orally active activator of PP2A.

PTP Inhibitor I is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor, it binds to PTPs with Ki values of 43 and 42 μM and Kinact values of 0.40 and 0.57/min for SHP-1(△SH2) and PTP1B, respectively.

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).