N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity.

Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction.

Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4.

Vesnarinone is a PDE3 inhibitor with IC50 value of 1.1μM for inhibiton of HERG current.

Ensifentrine is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively.

Prinoxodan is an inhibitor of phosphodiesterase.

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3).

BC 11-38 is a selective phosphodiesterase (PDE) 11 inhibitor with IC50 of 0.28 μM.

AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity with an IC50 of 0.49 μM and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.

Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.